Mitochondria and the Future of Medicine: The Key to Understanding Disease, Chronic Illness, Aging, and Life Itself

This is the best book I have read on mitochondria and pathologies, and thus I highly recommend it. For the medical nerd, like me (with the largest health website independent of industries) I find major pieces of the puzzle missing (parts that I am including in my book that is 2 years from publication). He misses the case made against sugar (Gary Taubes and Robert Lustig) and the conditions of affluence also called AGEs (advanced glycation end-products) which explain how sugar causes mitochondrial dysfunction. Fructose the reactive sugar bonds with proteins and polyunsaturated fats transported into the mitochondria. Lacking the fructose entails the harm fructose does through fructosylation.On the plus side is his excellent ability to communicate to a health educated audience, the many, many insights he has on processes. This book is a giant step forward for those struggling with the puzzle of our health disaster have not included mitochondria dysfunction. fructosylation is the reactive chemical that has overloaded the repair processes for the mitochondria. Most researchers on the right path stop with insulin resistance and too much refined carbohydrates. We should know more about our body than our car, thus read this book.

So much good information in this book, and it's put into a format that makes a really complicated subject easier to digest. I am recommending this book to everyone I know.Dr. Doug Wallace (considered the godfather of mitochondria research) is another great resource for all things mitos, but most of his talks on YT are geared towards clinicians.Another brilliant doctor, Dr. Jack Kruse, has figured out the quantum biological relationship between our light environment and mitochondria. I would highly recommend him as well if this is a subject that interests you. Turns out sunlight can fix a lot of our ills (and eliminating artificial blue light exposure through your eyes and skin), and this information is withheld (or represented as a poison, which is ridiculous) from the public because they haven't figured out how to charge us for sunlight...........yet.

Great book to get an understanding how your body produces the energy one needs to live. Is it the be all and end all to understanding all degenerative disease and the cause of ageing ? No doubt it's part of the cause but It seems to me that he kinda gave short thrift to other theories .Page 44 and 45 endocrine theory of ageing is caused by a fall in hormones but he doesn't mention HGH . His argument is why do these hormones start to fall in the first place. And seems to think that that ends the discussion..It doesn't! The question should be why shouldn't it fall over time? Consider this HGH repairs soft tissue damage including DNA damage done by free radicals. This may well be what keeps the young as healthy as they are. Evolution and natural selection only have one concern that we live long enuff to pass our genes along and stay alive long enuff to see our offspring to adulthood . Thus there's no REASON for the glands to continue producing HGH once the time has passed for that to be accomplished. But one can stimulate the production of HGH with proper exercise and diet. For more on this subject "Natural Hormonal Enhancement"can be gotten here on Amazon

Can someone please explain why Dr. Know released this book with a new title when it contains virtually the same content as his previous "LIFE - The epic story of our mitochondria"???It's STILL a great book, one that will change your understanding of the aging process. Dr. Know uses his knowledge of mitochondria and the mitochondrial theory of aging to elucidate the role of mitochondria in chronic disease, from cancer, heart disease, metabolic syndrom and diabetes to neurological diseases like Alzheimer's, Parkinson's, Huntington's, ALS, ADHD, anxiety and depression. He explains how understanding the role of mitochondria in chronic disease closes many of the holes left by the "Free Radical" theory of aging and suggests rational interventions that should result in healthier mitochondria and longer health span. Excellent job!

Mitochondria and the Future of Medicine is a fairly complex read. It's not for a complete beginner, though the author simplifies the over-all concepts in the beginning as much as he can. I would recommend this book to health care professionals to further their already solid base of knowledge in nutrition, the Krebs Cycle and metabolic disorders such as Diabetes, Metabolic Syndrome, Obesity, etc. Lee Know knows his material and presents it as clearly and concisely as he can, which is quite good, all the while reminding the reader that discoveries are continuously being made, causing our understanding to change. But the foundational information and its current ramifications Know puts forward, is exciting, fascinating and hopeful. I give it 5 stars. It's a solid piece of excellent work.

Illness is not "normal", even though it certainly has become the norm. We were not created to die horrible deaths from cancers, heart diseases, dementia, etc etc etc. Given proper deep nutrition (and exercise and rest), our bodies will perform the way they are designed to: for health and long life. The middle section of the book has a lot of fundamental biochemistry, and it goes a long way to help the reader understand why the author recommends what he does. He is neither cocky nor preachy, allowing the information to stand on it's own. Personally, I am on it!

Confirmed what I had an epiphany about when taking biochemistry in 1985 and wasn't believed. I later became an MD and had a pt with 3 kids who had mitochondrial disease issues. I was amazed I'd realized this all those years ago and but it was an epiphany. I how famous I'd have been had I chosen to have studied it but raising 3 kids before med school was more important. It's not the only time I've known things before they've been formally discovered.

Muy interesante y bien escrito, por lo que se facilita su lectura, a pesar de la complejidad del tema.

Very important overview of latest insights in what mitochondria do, how they work, and how with supplements we might help them function better. None of this was taught when I was in medical school.

A good introduction to mitochondria.I hope there will be an updated book in the near future, as the discoveries in mitochondrial influence on human health are evolving fast and the link between gut microbiota and mitochondria is fascinating.

Very good book and very informative

Livro com excelente explicação de aspectos básicos do funcionamento celular envolvidos com a mitocôndria, que serve de apoio para o desenvolver as relações patológicas e nutricionais relacionadas com a tese do autor quanto a disfunção mitocondrial. Excelente livro.