Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Second Edition

A comprehensive plus a practical guide for PKPD modelling.

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The 5th edition of “Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications” is a new, revised and expanded version of this PK/PD Bible that has been widely used for many years. It is valuable both as a text-book for beginners and as a reference book for more experienced scientists. The book contains numerous figures illustrating concepts and models.The first 3 Chapters cover general principles and pharmacokinetic and pharmacodynamic concepts. The 4th Chapter discusses modeling strategies and ends with a checklist for assessing goodness-of-fit for models. Chapter 5 discusses elements of design for kinetic and dynamic studies and what data and design are needed to answer specific questions. Chapter 6 is entirely new and is my favorite since it deals with pattern recognition and the value of actually looking at data and curve shape as diagnostic tools for proposing mechanisms and improving data analysis and linking data to actual biological processes.The second half of the book contains applications and case studies and the data sets are supplied on an attached USB memory stick. There are 53 PK case studies, including a few with large molecules (antibodies and enzyme), and 52 PD case studies. All exercises start with the objectives for the exercise, continue with a problem specification, describes the study design and data, the models used (with references to the concept chapters) and ends with a section on the interpretation of results and conclusions. These exercises are clearly indexed and start off with simple PK studies such as single dose bolus i.v. or p.o. studies and continue with more complex examples. There is also an excellent overview Table in Chapter 1, listing the case studies and the concepts on which they build.I strongly recommend this book to everybody working in this fieldYlva Terelius, PhD, Distinguished ScientistStockholm, Dec 2016

I bought this book due to the reputation of previous version(4th ed.), but am quite disappointed.1) The graph and table didn't look nice, why they were using shadow in the graph... Probably they were afraid of someone's copying the book, but the actual buyer was hard to read...2) The USB key was missing from the beginning, and I complained to Amazon... They responded that only the option was return and re-order. I looked up to the publisher's website but can't read because the site was written in Swedish!Sometime later, I found that the publisher provided CD-ROM for the data and code...Anyway, this was the one of terrible experiences I had...

A very useful book!PK/PD models are an important part of the process of drug development. This volumetric book supplies the reader simultaneously with nowadays theory and practice of this process.The volume has two clearly separated parts, the first is devoted to main concepts and the second contains application of the theoretical models. The material is well organized and easy of access.A very little mathematics is necessary to understand the matter. What I really like is the possibility to find without loss of time the model you need.The book covers a wide range of models used (and useful) in PK/PD modeling, linear as well as non-linear. One distinctive property of the text is the complete description and clear explanation of all the models.What I really miss is the lack of comparative description of easy acceptable software for PK/PD modeling. My suggestion to the authors of this remarkable book is to fill this gap in the future editions.prof. K.Kalinov, New Bulgarian University

This book is awesome (in terms of information)! The presentation is very poor --- graphics are terrible. What's with the blurry shadows around the graphs? You need to have Phoenix product to fully utilize this book. Organization needs serious improvements.

Great book but shadows on all figures, legends, and some equations make my eyes hurt and give me (and my colleagues) a headache. The drop shadows are so dark and large that it makes some of the plots indistinguishable. The shadow makes everything look blurry so your eyes continuously try to focus. Definitely need a new graphics designer and/or style guide for the next version.

I am a beginner of PK/PD modeling. I have found that this book is not for me. I have to make a lot of guess work to figure out how the formulas are derived in this book.

Complete and clear handbook on PK/PD modelling and simulation. I strongly recommend this book to everybody working in this field.