Is this the same as L-methyl Folate?

It's not exactly the same. The difference between Quatrefolic® and the calcium salt-based methylfolate forms is that the maker, Gnosis, bound the (6S) isomer of 5-MTHF (the “active nutritive ingredient” we care most about) to a different kind of salt molecule. Instead of using calcium salt, they use a glucosamine salt molecule. In 2010, Gnosis was officially recognized and approved by the FDA for its L-Methylfolate, Quatrefolic®, which is officially labeled as (6S)-5-Methylfolate, glucosamine salt. Quatrefolic® is said to be 99.9% pure, which again, just means that 99.9% of the 5-MTHF ingredient is made up of the glucosamine salt molecule that the (6S) isomer is bound to. However, when you ingest Quatrefolic®, the glucosamine salt molecule dissolves and the first pass absorption rate is only about 54-59%. So only about 56% of the (6S) isomer becomes available for absorption (the “active nutritive ingredient” that your body can use). This means that 1mg of Quatrefolic® equals approximately 0.56 mg of the active (6S)-5-MTHF (bioactive “free methylfolate”) that can be absorbed. So, with this version of methylfolate, you’re actually getting less of the actual (6S) isomer per mg of ingredient after the first pass absorption than you are with a calcium salt-based version. This means that, by weight, you would need more Quatrefolic® to equal the same amount of the effective (6S)-5-MTHF that a calcium salt-based version (like Metafolin®) contains. It is definitely worth noting, however, that the Quatrefolic® brand has been proven to get absorbed into the bloodstream faster than the Metafolin® brand, so this is something you may see marketed in products selling Quatrefolic®. When marketing notes that Quatrefolic® is “the most bioavailable methylfolate,” this just means it becomes available faster for the body to absorb. This faster absorption rate may make a difference in how one feels symptomatically when taking Quatrefolic® vs. Metafolin®: you could experience positive or negative methylation results faster. I have heard of some people encountering side effects based on one vs. the other salt type. So just be aware as you take your methylfolate that you may be fine with one salt type and have trouble with the other (or you may be fine with both!). Pay attention to your body and switch to a different type if you think the salt version might be causing you problems.

Where are the supplement facts? ALL the ingredients?

There on the back of the bottle. 400 mcg of folate. Other ingredients is cellulose, magnesium stearate and gelatin. Hope this helps. It's also the kind that is better absorbed than straight folate. Caio

How soon wiill I begin to notice improvement in my anxiety level? I've been taking if for 4 days and I don't really notice anything much yet.Thanks

It may also depend on how deficient you are. I have borderline macrocytosis thought to be due to b12/folate deficiency. I noticed a huge difference in mood the first day I took a sublingual methylb12/methylfolate combo. I hadn't known it could effect mood when I started it, just hemodynamics, so I don't feel placebo effect was a factor. My brother with similar genetic predispositions did not notice a difference in the first 6 days he tried it, but he does not have obvious blood abnormalities indicating deficiency. I wish I'd started and kept taking it at his age before I had as much impact as now. Good luck

Where is this produced? What is the country of origin?

The bottle reads "Distributed Exclusively by Jarrow Formulas". It does not indicate origin so you would have to contact them www.jarrow.com.

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Reviews

S**A

Excellent product, excellent selling service

Good product, arrived on time. Seller send a very useful gift. Highly recommended, will buy again to FITINAT.

25.08.2024

ا**.

استشرت طبيبتي قالت انه يفي بالغرض

29.11.2023

M**G

Oine

It's amazing website for purchasing online really it was fantastic

25.04.2021

H**D

مفيد

9.09.2020

H**E

Horrible

This supplement made me severely agitated and short tempered. I only took it for few days and It made me feel extremely depressed. And that feeling went away when I stopped it.

16.08.2024

A**M

I bought it it was open and can't return it

The medicine was open

19.11.2020

A**A

Old

27.09.2021

J**1

At first I was a bit wary of trying Methylated Folate as it can have negative side effects for some people, but I'm glad I did. My Folate levels were incredibly low. I was anemic in both B12 and Iron. I am compound heterozygous for the MTHFR gene and have several other mutations. This product has done wonders. I have used Jarrow in the past and liked their quality so I was happy to see that they carried this. I've been taking this every morning for months now and instead of my folate levels continuously being on my bloodwork, it's finally staying at the correct levels. I did stop using it for a while per my Doctors instructions and it dropped again, so I will continue this for the forseeable future.

6.11.2025

N**R

افضل من حمض الفوليك اللي تاخذه الحوامل لأن هذا صيغة فولات

7.08.2024

A**Y

Excelentes ácido fólico

30.12.2025

P**.

Me encantó esté folato súper ayuda no solo a mi si no a mi esposo le ayudo mucho también

18.11.2025

R**0

This pill brought up my deficient folate level pretty fast. Measured in 1.5 months after starting the supplement, one pill once a day, the level was back to normal. I also appreciate the pill being natural and easily absorbed. I swallow the pill with a cup of water-no bad taste.

16.12.2025

ASIN	B007LEO3OW
ASIN	B007LEO3OW
Age Range Description	Adult
Allergen Information	Peanut Free
Best Sellers Rank	#2,654 in Health ( See Top 100 in Health ) #23 in Vitamin B Supplements
Brand	Jarrow Formulas
Customer Reviews	4.7 4.7 out of 5 stars (5,234)
Customer reviews	4.7 4.7 out of 5 stars (5,234)
Date First Available	6 August 2012
Format	Capsule
Is Discontinued By Manufacturer	No
Item model number	5MTHF
Manufacturer	Jarrow Formulas
Product Dimensions	4.45 x 4.45 x 8.26 cm; 20 g
Units	60 Count
Weight	10 Grams

Methyl Folate, 400 Mcg, 60 Capsules

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